Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity

نویسندگان

  • Heba J. Sabbagh
  • Nicola P. Innes
  • Bahauddin I. Sallout
  • Najlaa M. Alamoudi
  • Mustafa A. Hamdan
  • Nasir Alhamlan
  • Amaal I. Al-Khozami
  • Fatma D. Abdulhameed
  • Jumana Y. Al-Aama
  • Peter A. Mossey
چکیده

OBJECTIVES To describe the characteristics and prevalence of non-syndromic orofacial clefting (NSOFC) and assess the effects of parental consanguinity on NSOFC phenotypes in the 3 main cities of Saudi Arabia. METHODS All infants (114,035) born at 3 referral centers in Riyadh, and 6 hospitals in Jeddah and Madinah between January 2010 and December 2011 were screened. The NSOFC cases (n=133) were identified and data was collected through clinical examination and records, and information on consanguinity through parent interviews. The diagnosis was confirmed by reviewing medical records and contacting the infants' pediatricians. Control infants (n=233) matched for gender and born in the same hospitals during the same period, were selected. RESULTS The prevalence of NSOFC was 1.07/1000 births in Riyadh, and 1.17/1000 births overall; cleft lip (CL) was 0.47/1000 births, cleft lip and palate (CLP) was 0.42/1000 births, and cleft palate (CP) was 0.28/1000 births. Cleft palate was significantly associated with consanguinity (p=0.047, odds ratio: 2.5, 95% confidence interval: 1 to 6.46), particularly for first cousin marriages. CONCLUSION The birth prevalence of NSOFC in Riyadh alone, and in the 3 main cities of Saudi Arabia were marginally lower than the mean global prevalence. While birth prevalence for CLP was comparable to global figures, the CL:CLP ratio was high, and only CP was significantly associated with consanguinity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants

Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts. Materials and methods:In this study 105 Iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...

متن کامل

Prevalence of non-syndromic orofacial clefts among Jews and Arabs, by type, site, gender and geography: a multi-center study in Israel.

BACKGROUND Orofacial clefts are the most common craniofacial congenital malformations, with significant anatomic, ethnic, racial and gender differences. OBJECTIVES To investigate the prevalence, distribution and characteristic features of various types of non-syndromic clefts among Israeli Jews and Arabs. METHODS We conducted a retrospective multi-center survey in 13 major hospitals in Isra...

متن کامل

Reduction in non syndromic oral clefts following mandatory flour fortification with folic acid in Northern Iran

  Background: Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran.   Methods : In this hospital based study from March 2006 to September 2009, we screened the total number of live births at all hospitals in Golestan pro...

متن کامل

Diagnostic implications of associated defects in patients with typical orofacial clefts.

OBJECTIVES To describe prevalence of associated defects and clinical-genetic characteristics of patients with typical orofacial clefts seen at a reference genetic service. METHODS Descriptive study conducted between September of 2009 and July of 2014. Two experienced dysmorphologists personally collected and coded clinical data using a validated, standard multicenter protocol. Syndromic cases...

متن کامل

1 st July 2016 Apex City Quay Hotel West Victoria Dock

1: The evidence base for intervention with respect to smoking and consanguinity. Meta-analyses reveal that passive smoking and consanguinity ARE both risk factors in OFC. Mossey, P.A. “Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis”. Sabbagh HJ, Hassan MH, Innes NP, Elkodary HM, Little J, Mossey PA Data extraction from studies reporting ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 36  شماره 

صفحات  -

تاریخ انتشار 2015